关键词: 小鼠, 物体位置辨别测试, 学习记忆

Abstract: Objective　To investigate the effects of shape, color, and interval time on object position discrimination in mice.Methods　A total of 90 male C57 mice were randomly assigned to three groups: shape (27 mice), color (27 mice), and interval time (36 mice). Each group underwent tests involving various object shapes, colors, and test intervals to assess the object position discrimination index, which was used to evaluate the mice′s learning and memory abilities. Results　In the shape test, mice demonstrated the highest discrimination index for square objects (P<0.05). In contrast, there were no significant differences in the object discrimination index across different colors. For the interval time test, the discrimination indices were significantly higher for the 10-minute and 1-hour intervals (P<0.05). Conclusion　Both object shape and interval time appear to influence the object position discrimination test in mice. Specifically, a 1-hour interval between object presentation and square objects testing resulted in a higher discrimination index.

Key words: mice, object position discrimination test, learning and memory